Arctic Bioscience – New positive data showing anti-inflammatory effects of phospholipid esters from herring roe in immune cells

Arctic Bioscience are today presenting a new data on anti-inflammatory cellular functions of herring roe oil at the 9th European Workshop on Lipid Mediators in Edinburgh, UK.

"We are very pleased to announce new positive data on the anti-inflammatory properties related to our investigational medicine, HRO350. The data show an effect on cells which may also have benefit in other inflammatory diseases, which we will explore further", says CEO Christer L. Valderhaug.

“These data are important because they illuminate a mechanism of action of HRO350, which is currently being tested in a phase 2b clinical trial for mild-to-moderate psoriasis. Scientifically, this is state-of-the-art lipidomics, and we have collaborated with a key international research group in this field. We are also proud that this research has been conducted in Norway, with cellular researchers at Møreforsking”, says Medical Director Runhild Gammelsæter.

The HeROPA clinical trial on HRO350 with the active substance Phospholipid Esters from Herring Roe (PeHeRo) is ongoing in mild-to-moderate psoriasis, with planned read-out fall 2024.

These new data on human primary immune cells show that Phospholipid Esters from Herring Roe promotes biosynthesis of specialized pro-resolving mediators (SPMs) that are involved in anti-inflammatory activities. This mode of action can be a promising treatment modality in inflammatory conditions, including psoriasis, and supports an anti-inflammatory action of the investigational medicinal product HRO350. These data support previously published effects on inflammatory markers in psoriasis (Petrovic 2023).

“Our chemists in the R&D department have been working on this research project for three years, and we are very excited to see the effects of the extracts we have developed in our lab”, says CTO Daniele Mancinelli.

The study was conducted in collaboration with Møreforsking and was supported with a grant from the Norwegian Research Council (project nr. 327953, Properties of phospholipids from Herring Roe in Psoriasis).

Reference: Ringheim-Bakka T, Mildenberger J, Dalli J, Saliani A, Petrucelli F, Busygina M, Mancinelli D, Gammelsæter R. “Phospholipid Esters from Herring Roe promotes SPM biosynthesis in human monocyte-derived macrophages with implications for the treatment of psoriasis”. Poster at the 9th European Workshop on Lipid Mediators, June 26-28th, 2024.

The poster will be made available on the IR tab on the company’s webpage.

This information is subject to the disclosure requirements pursuant to section 5-12 of the Norwegian Securities Trading Act.